Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914913 | 0.79 | ADORA2A (0.48) | CYP11B2KDM4EGAAGLAATM | |
| SCHEMBL29910019 | 0.76 | BRD4 (0.42) | HPGDSNPC1RAB9A | |
| SCHEMBL368250 | 0.74 | HPGDS (0.58) | CHRNB2CHRNA5CHRNA4KDM4EHPGDS | |
| SCHEMBL2146565 | 0.72 | KDM4E (0.52) | CYP11B2KDM4EGAAHSD17B10ALDH1A1 | |
| SCHEMBL20240078 | 0.72 | KDM4E (0.49) | CYP11B2KDM4EGAAGLAHSD17B10 | |
| SCHEMBL14856915 | 0.71 | ESR2 (0.55) | CYP11B2KDM4EGAAGLAHSD17B10 | |
| SCHEMBL30630392 | 0.71 | ESR2 (0.55) | CYP11B2KDM4EGAAGLAHSD17B10 | |
| SCHEMBL31264147 | 0.71 | ESR2 (0.55) | CYP11B2KDM4EGAAGLAHSD17B10 | |
| SCHEMBL28721464 | 0.70 | KDM4E (0.50) | CYP11B2KDM4EGAAGLAHSD17B10 | |
| SCHEMBL2146568 | 0.69 | NISCH (0.49) | CYP11B2KDM4EGAAGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | claimed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | claimed |