Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737264 | 0.89 | SYK (0.62) | SYKKCNH2CYP2C9CYP2D6LRRK2 | |
| SCHEMBL14751331 | 0.86 | SYK (0.72) | SYKKCNH2CYP2C9CYP2D6LRRK2 | |
| SCHEMBL14736829 | 0.81 | SYK (0.66) | SYKKCNH2CYP2C9CYP2D6LRRK2 | |
| SCHEMBL14737320 | 0.79 | SYK (1.00) | SYKKCNH2CYP2C9CYP2D6 | |
| SCHEMBL14747115 | 0.78 | SYK (0.49) | SYKLRRK2 | |
| SCHEMBL14738512 | 0.75 | SYK (0.63) | SYKKCNH2CYP2C9CYP2D6 | |
| SCHEMBL14737773 | 0.74 | SYK (0.43) | SYK | |
| SCHEMBL14744517 | 0.73 | SYK (0.42) | SYKKCNH2CYP2C9CYP2D6 | |
| SCHEMBL14738497 | 0.72 | MAOA (0.35) | SYK | |
| SCHEMBL14738886 | 0.72 | SYK (0.48) | SYKKCNH2CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |