Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747226 | 0.86 | CHRM1 (0.50) | CHRM1MAPTRXFP1HTTLMNA | |
| SCHEMBL2884792 | 0.84 | CHRM1 (0.64) | CHRM1LMNAALDH1A1 | |
| SCHEMBL2877481 | 0.84 | CHRM1 (0.86) | CHRM1MAPTHTTLMNA | |
| SCHEMBL2880298 | 0.83 | CHRM1 (0.62) | CHRM1MAPTRAB9ALMNASMN1; SMN2 | |
| SCHEMBL2486081 | 0.81 | CHRM1 (0.76) | CHRM1MAPTHTTMCL1ALDH1A1 | |
| SCHEMBL2882158 | 0.80 | CHRM1 (0.68) | CHRM1HTTLMNAALDH1A1 | |
| SCHEMBL2486076 | 0.80 | CHRM1 (1.00) | CHRM1LMNA | |
| SCHEMBL14307347 | 0.78 | CHRM1 (0.58) | CHRM1MAPTRXFP1HTTLMNA | |
| SCHEMBL2486523 | 0.78 | CHRM1 (0.58) | CHRM1HTTALDH1A1 | |
| SCHEMBL2883197 | 0.78 | CHRM1 (0.80) | CHRM1LMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |