Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | WDR91 | A4D1P6 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911888 | 0.84 | ZAP70 (0.49) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL12311809 | 0.84 | ZAP70 (0.49) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL10207986 | 0.84 | ZAP70 (0.49) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL29809917 | 0.83 | NOTUM (0.51) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL22398883 | 0.83 | NOTUM (0.51) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL2448228 | 0.82 | WDR91 (0.51) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL1911872 | 0.81 | ZAP70 (0.49) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL2559261 | 0.81 | RAB9A (0.47) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL2445431 | 0.80 | NOTUM (0.65) | ALDH1A1HSD17B10KDM4EHPGDPRKDC | |
| SCHEMBL2941204 | 0.80 | NOTUM (0.64) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |