Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14749336 | 0.87 | PRCP (0.55) | PRCPALDH1A1KCNQ3KCNQ2 | |
| SCHEMBL14749364 | 0.87 | PRCP (0.55) | PRCPALDH1A1KCNQ3KCNQ2 | |
| SCHEMBL14749417 | 0.87 | PRCP (0.51) | PRCPCYP2C9KMT2ACYP1A2CYP3A4 | |
| SCHEMBL12184132 | 0.86 | PRCP (0.51) | PRCPCYP2C9EPHX2KMT2AALDH1A1 | |
| SCHEMBL14736554 | 0.85 | PRCP (0.51) | PRCPEPHX2ALDH1A1 | |
| SCHEMBL14749394 | 0.85 | PRCP (0.56) | PRCPCYP2C9EPHX2KMT2AALDH1A1 | |
| SCHEMBL14749412 | 0.85 | PRCP (0.50) | PRCPCYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14749414 | 0.84 | PRCP (0.51) | PRCPCYP2C9EPHX2CYP1A2CYP3A4 | |
| SCHEMBL14736875 | 0.84 | PRCP (0.59) | PRCPCYP2C9KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14749388 | 0.84 | PRCP (0.54) | PRCPCYP2C9EPHX2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP | 2013-03-07 | — | — | US | disclosed |
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | PRCP 1/4885CYP2C9 1027/4885EPHX2 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.