Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.45 |
| ▸ | JAK1 | P23458 | 11/20 | 0.45 |
| ▸ | JAK3 | P52333 | 10/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747007 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL18534786 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746993 | 0.91 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14750178 | 0.91 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746923 | 0.90 | SYK (0.44) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14750190 | 0.90 | SYK (0.44) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746987 | 0.88 | SYK (0.46) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746951 | 0.88 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746957 | 0.87 | SYK (0.47) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746980 | 0.87 | SYK (0.46) | JAK2JAK1JAK3TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | JAK2 5/4885JAK1 3/4885JAK3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.