Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.45 |
| ▸ | JAK1 | P23458 | 11/20 | 0.45 |
| ▸ | JAK3 | P52333 | 10/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747007 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14752197 | 1.00 | JAK2 (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746993 | 0.91 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14750178 | 0.91 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746923 | 0.90 | SYK (0.44) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14750190 | 0.90 | SYK (0.44) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746987 | 0.88 | SYK (0.46) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746951 | 0.88 | SYK (0.45) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746957 | 0.87 | SYK (0.47) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746980 | 0.87 | SYK (0.46) | JAK2JAK1JAK3TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |