Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 8/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984903 | 0.86 | KAT2B (0.79) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL15984907 | 0.83 | KAT2B (0.97) | KAT2BPKMPOLBMAPTPRSS1 | |
| Hydrochloric Acid SCHEMBL513299 | 0.82 | KAT2B (1.00) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL10113238 | 0.78 | KAT2B (1.00) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL29416813 | 0.78 | KAT2B (1.00) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL10113236 | 0.78 | KAT2B (0.66) | KAT2BPKMPOLBMAPTPRSS1 | |
| Hydrochloric Acid SCHEMBL513245 | 0.77 | KAT2B (1.00) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL10622798 | 0.76 | KAT2B (0.72) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL7451286 | 0.76 | KAT2B (0.50) | KAT2BPKMPOLBMAPTPRSS1 | |
| SCHEMBL29154963 | 0.75 | KAT2B (0.58) | KAT2BPKMPOLBMAPTPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015081280-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2015081284-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2013033270-A2 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033269-A1 | BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |