Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.85 |
| ▸ | BRD2 | P25440 | 2/20 | 0.78 |
| ▸ | SMCHD1 | A6NHR9 | 1/20 | 0.78 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.78 |
| ▸ | AIP | O00170 | 1/20 | 0.78 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.78 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.78 |
| ▸ | CDC7 | O00311 | 1/20 | 0.78 |
| ▸ | SAP18 | O00422 | 1/20 | 0.78 |
| ▸ | KPNA3 | O00505 | 1/20 | 0.78 |
| ▸ | PPP6C | O00743 | 1/20 | 0.78 |
| ▸ | TCERG1 | O14776 | 1/20 | 0.78 |
| ▸ | UBE2L6 | O14933 | 1/20 | 0.78 |
| ▸ | PPP1R12A | O14974 | 1/20 | 0.78 |
| ▸ | U2SURP | O15042 | 1/20 | 0.78 |
| ▸ | SETD1A | O15047 | 1/20 | 0.78 |
| ▸ | ARPC1B | O15143 | 1/20 | 0.78 |
| ▸ | POLR1C | O15160 | 1/20 | 0.78 |
| ▸ | OGT | O15294 | 1/20 | 0.78 |
| ▸ | PPM1G | O15355 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24937877 | 1.00 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL14756416 | 0.92 | BRD4 (1.00) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL1820357 | 0.92 | BRD4 (1.00) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL19556889 | 0.92 | BRD4 (0.86) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL15980801 | 0.92 | BRD4 (0.86) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL17451427 | 0.92 | BRD4 (1.00) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL16758462 | 0.91 | BRD4 (0.70) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL29380345 | 0.91 | BRD4 (1.00) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL24301340 | 0.91 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL12671507 | 0.91 | BRD4 (1.00) | BRD4BRD2SMCHD1MYO1GAIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014124-A1 | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-10905768-B1 | Heterocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200140456-A1 | N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-05-07 | — | — | US | disclosed |
| WO-2015081280-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014124-A1 | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | CRBN, MDM2, STUB1 | BRD4 376/4885BRD2 435/4885SMCHD1 4356/4885 |
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | STUB1, UBE3C, UBE3A | BRD4 922/4885BRD2 1310/4885SMCHD1 2738/4885 |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | STUB1, UBE3C, UBE3A | BRD4 922/4885BRD2 1310/4885SMCHD1 2738/4885 |
| US-10905768-B1 | Heterocyclic degronimers for target protein degradation | CRBN, MDM2, STUB1 | BRD4 376/4885BRD2 435/4885SMCHD1 4356/4885 |
| US-20200140456-A1 | N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION | CRBN, CBL, STUB1 | BRD4 1667/4885BRD2 1602/4885SMCHD1 4259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.