STUB1

E3 ubiquitin-protein ligase CHIP · Q9UNE7 · STUB1 on Sugi Atlas →

271 patent compounds predicted against STUB1, 227 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8288590 SCHEMBL8288590 0.76 1/20
SCHEMBL7003055 SCHEMBL7003055 0.74 1/20
SCHEMBL5451446 SCHEMBL5451446 0.71 1/20
SCHEMBL5453282 SCHEMBL5453282 0.71 1/20
SCHEMBL7002920 SCHEMBL7002920 0.70 1/20
SCHEMBL5460515 SCHEMBL5460515 0.69 1/20
SCHEMBL8289514 SCHEMBL8289514 0.69 1/20
SCHEMBL13574989 SCHEMBL13574989 0.69 1/20
SCHEMBL8288668 SCHEMBL8288668 0.68 1/20
SCHEMBL8289505 SCHEMBL8289505 0.68 1/20
SCHEMBL11324603 SCHEMBL11324603 0.66 1/20
SCHEMBL26293177 SCHEMBL26293177 0.64 1/20
SCHEMBL5449182 SCHEMBL5449182 0.63 1/20
SCHEMBL26294993 SCHEMBL26294993 0.63 1/20
SCHEMBL1067537 SCHEMBL1067537 0.62 1/20
SCHEMBL8289822 SCHEMBL8289822 0.62 1/20
SCHEMBL7003174 SCHEMBL7003174 0.62 1/20
SCHEMBL8277600 SCHEMBL8277600 0.62 1/20
SCHEMBL1066142 SCHEMBL1066142 0.62 1/20
SCHEMBL23657531 SCHEMBL23657531 0.62 1/20

Clinical trials — most relevant to STUB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients PHASE4NOT_YET_RECRUITING
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study PHASE2WITHDRAWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease EARLY_PHASE1RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin nanUNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors nanNOT_YET_RECRUITING
CHIP/CCUS Natural History Protocol nanRECRUITING
Biomarkers in Samples of Bone Marrow From Patients With Acute Myeloid Leukemia nanCOMPLETED
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
Clonal Hematopoiesis is a Risk Factor for Chemotherapy-Related Complications nanRECRUITING
Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia nanCOMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure nanCOMPLETED
Clonal Hematopoiesis of Indeterminate Potential and Accelerated Atherosclerosis in Systemic Lupus Erythematosus nanCOMPLETED
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children nanCOMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
Using Mobile Technology to Improve Self-Regulation nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients nanUNKNOWN
Study of DNA Samples From Patients With Multiple Myeloma nanCOMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults nanUNKNOWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma nanCOMPLETED
Establishment of a Prospective Clinical-biological Database nanRECRUITING
Genetic Landscape in Women with Metastatic Ovarian Cancer Before and During Treatment with PARP Inhibitors nanRECRUITING
Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury nanCOMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a STUB1 binder may also engage these)

ProteinNameSimilarity
Q9WUD1 1.000 Q9WUD1 →
Q5ZHY5 0.997 Q5ZHY5 →
A6HD62 0.997 A6HD62 →
Q5ZLF0 0.952 Q5ZLF0 →
Q6NYU2 0.952 Q6NYU2 →
Q91W86 0.951 Q91W86 →
Q9H269 0.951 Q9H269 →
Q2KJ46 0.951 Q2KJ46 →
Q9H270 0.950 Q9H270 →
D2XV59 0.950 D2XV59 →
P50503 0.949 P50503 →
PSMD3 26S proteasome non-ATPase regulatory subunit 3 0.949 landscape →
A4QNE0 0.949 A4QNE0 →
Q676U5 0.949 Q676U5 →
PPME1 Protein phosphatase methylesterase 1 0.949 landscape →
Q5BK32 0.948 Q5BK32 →
Q9CZW5 0.948 Q9CZW5 →
Q7L5D6 0.947 Q7L5D6 →
Q496Y0 0.947 Q496Y0 →
Q75Q39 0.947 Q75Q39 →
Q9D1H7 0.947 Q9D1H7 →
Q6N069 0.947 Q6N069 →
Q5BJZ6 0.947 Q5BJZ6 →
Q5RAC9 0.947 Q5RAC9 →
P14685 0.947 P14685 →
Q9Z0G0 0.946 Q9Z0G0 →
Q6TGY8 0.946 Q6TGY8 →
Q5XGS8 0.946 Q5XGS8 →
Q920Q4 0.946 Q920Q4 →
EMC2 ER membrane protein complex subunit 2 0.946 landscape →