Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | NPC1 | O15118 | 7/20 | 0.77 |
| ▸ | RAB9A | P51151 | 7/20 | 0.77 |
| ▸ | MEN1 | O00255 | 7/20 | 0.77 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757176 | 0.91 | KMT2A (0.79) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757353 | 0.88 | NPC1 (0.81) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757204 | 0.87 | NPC1 (1.00) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757235 | 0.87 | RAB9A (0.79) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14741353 | 0.86 | KMT2A (0.78) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757232 | 0.86 | NPC1 (0.78) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757333 | 0.86 | RAB9A (0.78) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757297 | 0.84 | KMT2A (0.86) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757278 | 0.83 | KMT2A (0.84) | KMT2ANPC1RAB9AMEN1RXFP1 | |
| SCHEMBL14757374 | 0.83 | KMT2A (0.84) | KMT2ANPC1RAB9AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013032907-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER STEM CELLS | THE BROAD INSTITUTE, INC. (US) | 2013-03-07 | — | — | WO | disclosed |