Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.70 |
| ▸ | SCD | O00767 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757279 | 0.85 | GCK (0.71) | GCKSCDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14757228 | 0.84 | GCK (0.74) | GCKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL14757305 | 0.82 | GCK (0.73) | GCKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL14757383 | 0.80 | KMT2A (0.76) | GCKSCDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14757302 | 0.80 | GCK (0.71) | GCKSCDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2664786 | 0.76 | GCK (0.61) | GCKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8560618 | 0.74 | GCK (0.79) | GCKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1270190 | 0.74 | NPC1 (1.00) | GCKSCDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2664756 | 0.74 | GCK (0.48) | GCKSCDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3509220 | 0.73 | NPC1 (0.75) | GCKNPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013032907-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER STEM CELLS | THE BROAD INSTITUTE, INC. (US) | 2013-03-07 | — | — | WO | disclosed |