⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101659 | 0.76 | HDAC8 (0.34) | — | |
| SCHEMBL12938268 | 0.75 | HDAC8 (0.36) | — | |
| SCHEMBL29502328 | 0.75 | — | — | |
| SCHEMBL9747522 | 0.73 | — | — | |
| SCHEMBL25283800 | 0.71 | — | — | |
| SCHEMBL30471742 | 0.71 | — | — | |
| SCHEMBL31387318 | 0.71 | — | — | |
| SCHEMBL4932975 | 0.71 | — | — | |
| SCHEMBL15024923 | 0.71 | HDAC8 (0.34) | — | |
| SCHEMBL30673294 | 0.71 | HDAC8 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104610138-A | Method for synthesizing ethylenediamine tetraacetic acid type probe for protein paramagnetic labeling | UNIV NANKAI | 2015-05-13 | — | — | CN | claimed |
| US-20250026743-A1 | HETEROARYL-LINKED ANALOGS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY | 2025-01-23 | — | — | US | disclosed |
| CN-119080686-A | Water-soluble fluorescent probe and preparation method and application thereof | 河南省化工研究所有限责任公司 | 2024-12-06 | — | — | CN | disclosed |
| US-12065409-B2 | Analogs of 2-pralidoxime as antidotes against organophosphorus nerve agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2024-08-20 | — | — | US | disclosed |
| EP-4402140-A1 | HETEROARYL-LINKED ANALOGS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | Vanderbilt University (US) | 2024-07-24 | — | — | EP | disclosed |
| CN-118251390-A | Heteroaryl linked analogs as MGLU5 negative allosteric modulators and methods of making and using the same | 范德比尔特大学 | 2024-06-25 | — | — | CN | disclosed |
| WO-2023043833-A1 | HETEROARYL-LINKED ANALOGS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2023-03-23 | — | — | WO | disclosed |
| US-20210317084-A1 | Analogs of 2-Pralidoxime as Antidotes Against Organophosphorus Nerve Agents | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2021-10-14 | — | — | US | disclosed |
| WO-2020027905-A2 | ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-02-06 | — | — | WO | disclosed |
| US-10428043-B2 | Green oxidation catalytic system | TRUSTEES OF BOSTON UNIVERSITY (US) | 2019-10-01 | — | — | US | disclosed |
| US-7501411-B2 | Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS, NV (BE) | 2009-03-10 | — | — | US | disclosed |
| US-7501411-B2 | Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS, NV (BE) | 2009-03-10 | — | — | US | disclosed |
| US-20080090818-A1 | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases | GALAPAGOS NV (BE) | 2008-04-17 | — | — | US | disclosed |
| US-20080090818-A1 | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases | GALAPAGOS NV (BE) | 2008-04-17 | — | — | US | disclosed |
| CN-101048408-A | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity | IRM LLC (BM) | 2007-10-03 | — | — | CN | disclosed |
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | disclosed |
| EP-0767172-B1 | 8-Arylalkyl- and 8-arylheteroalkyl-5, 11-dihydro-6H-dipyrido-[3,2-b:2', 3'-e][1,4]diazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 2003-03-26 | — | — | EP | disclosed |
| US-5705499-A | VIRICIDES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0767172-A1 | 8-Arylalkyl- and 8-arylheteroalkyl-5, 11-dihydro-6H-dipyrido-[3,2-b:2', 3'-e][1,4]diazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1997-04-09 | — | — | EP | disclosed |