Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675015 | 0.89 | GRK6 (0.36) | KMT2AMEN1MAPTALOX15USP2 | |
| SCHEMBL589957 | 0.85 | MEN1 (0.47) | KMT2AMEN1MAPTALOX15USP2 | |
| SCHEMBL591459 | 0.83 | MEN1 (0.45) | KMT2AMEN1MAPTALOX15USP2 | |
| SCHEMBL589273 | 0.82 | MEN1 (0.44) | KMT2AMEN1MAPTALOX15USP2 | |
| SCHEMBL729612 | 0.82 | ADRB2 (0.39) | ALOX15ALDH1A1GRK6KDM4E | |
| SCHEMBL15077883 | 0.76 | KCNH2 (0.45) | ALOX15NPSR1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7576971 | 0.76 | KCNH2 (0.37) | KMT2AMEN1MAPTALOX15USP2 | |
| SCHEMBL729608 | 0.75 | KCNH2 (0.45) | ALOX15ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL729609 | 0.75 | KCNH2 (0.45) | ALOX15ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL7496082 | 0.75 | KCNH2 (0.48) | KMT2AMEN1MAPTALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664062-B1 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS INC (US) | 2013-03-13 | — | — | EP | disclosed |