Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14759047 | 0.81 | KDM4E (0.37) | KDM4EPKMALDH1A1CYP3A4TSHR | |
| SCHEMBL12180101 | 0.79 | KDM4E (0.41) | KDM4EPKMALDH1A1CYP3A4TSHR | |
| SCHEMBL2592915 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1RECQLGAAKMT2A | |
| SCHEMBL14717777 | 0.74 | EZH2 (0.42) | KDM4EPKMEZH2EEDRBBP4 | |
| SCHEMBL14917611 | 0.71 | GRIN2D (0.46) | KDM4EPKMALDH1A1MAPK1GAA | |
| SCHEMBL17734330 | 0.71 | KDM4E (0.47) | KDM4EPKMALDH1A1TSHRMAPK1 | |
| SCHEMBL17029365 | 0.69 | ALDH1A1 (0.36) | KDM4EALDH1A1GAAEZH2GLA | |
| SCHEMBL14917584 | 0.69 | ALDH1A1 (0.33) | KDM4EPKMALDH1A1CYP3A4TSHR | |
| SCHEMBL8265173 | 0.68 | MAPK1 (0.54) | KDM4EALDH1A1MAPK1GAAKMT2A | |
| SCHEMBL27893012 | 0.67 | MEN1 (0.49) | PKMTSHRKMT2AMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |