Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.82 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.74 |
| ▸ | KRAS | P01116 | 5/20 | 0.74 |
| ▸ | CA1 | P00915 | 3/20 | 0.74 |
| ▸ | CA2 | P00918 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14760794 | 1.00 | ABCB1 (0.82) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL16257540 | 0.90 | ABCB1 (0.65) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL29803052 | 0.87 | NR1H4 (0.74) | ABCB1ABCG2CA1CA2CYP1A1 | |
| SCHEMBL16257539 | 0.87 | NR1H4 (0.74) | ABCB1ABCG2CA1CA2CYP1A1 | |
| SCHEMBL499524 | 0.85 | ABCG2 (1.00) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL29803073 | 0.85 | ABCG2 (1.00) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL14922407 | 0.85 | ABCG2 (1.00) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL31374858 | 0.85 | KRAS (1.00) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL11796142 | 0.85 | ABCB1 (0.83) | ABCB1ABCG2KRASCA1CA2 | |
| SCHEMBL11796150 | 0.85 | ABCB1 (0.83) | ABCB1ABCG2KRASCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889874-B2 | Imidazolone-chalcone derivatives as potential anticancer agent and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-11-18 | — | — | US | disclosed |
| EP-2523941-B1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-10-15 | — | — | EP | disclosed |
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | SIK1, SIK2, SIK3 | ABCB1 571/4885ABCG2 390/4885KRAS 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.