SCHEMBL1476302

SCHEMBL1476302

Cc1cc([C@@H](C)NC(=O)C2CC2(CO)c2ccc(C(C)(C)C)cc2)ccc1[AsH]S(C)(=O)=O

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.34
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1474633 0.86 TRPV1 (0.43) TRPV1
SCHEMBL27699466 0.80 HPGD (0.33) TRPV1HPGD
SCHEMBL12827246 0.79 NR1H4 (0.34) HPGD
SCHEMBL13685242 0.76 TRPV1 (0.41) TRPV1
SCHEMBL1474664 0.71 TRPV1 (0.39) TRPV1
SCHEMBL1474486 0.70 TRPV1 (0.43) TRPV1
SCHEMBL13685241 0.70 TRPV1 (0.43) TRPV1
SCHEMBL1476869 0.70 CHRNA7 (0.38) TRPV1
SCHEMBL1474311 0.66 TRPV1 (0.48) TRPV1
SCHEMBL13685551 0.66 TRPV1 (0.48) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7915448-B2 Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists PFIZER INC. (US) 2011-03-29 US claimed