Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | PGK1 | P00558 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771501 | 0.94 | NQO2 (0.57) | NQO2MAPTALDH1A1PRNPNPSR1 | |
| SCHEMBL16052827 | 0.85 | NQO2 (0.39) | NQO2MAPTALDH1A1PRNPNPSR1 | |
| SCHEMBL16052516 | 0.82 | PDE2A (0.38) | NQO2PDE10APGK1PDE2APDE5A | |
| SCHEMBL14764356 | 0.77 | NQO2 (0.62) | NQO2MAPTALDH1A1PRNPNPSR1 | |
| SCHEMBL14764689 | 0.76 | NQO2 (0.56) | NQO2MAPTALDH1A1NPC1LMNA | |
| SCHEMBL14764559 | 0.74 | NQO2 (0.62) | NQO2MAPTALDH1A1PRNPNPSR1 | |
| SCHEMBL14475211 | 0.70 | PABPC1 (0.47) | MAPTALDH1A1RXFP1POLBRAB9A | |
| SCHEMBL14475228 | 0.70 | PABPC1 (0.47) | MAPTALDH1A1RXFP1POLBRAB9A | |
| SCHEMBL14764659 | 0.70 | NQO2 (0.56) | NQO2MAPTALDH1A1NPC1LMNA | |
| SCHEMBL16052610 | 0.70 | GRM5 (0.36) | MAPTALDH1A1PDE10APDE2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139983-A1 | [1,2,4]TRIAZOLO[4,3-A]QUINOXALINES AS DUAL PDE2/PDE10 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |