SCHEMBL14764623

SCHEMBL14764623

CC(C(=O)O)C(=O)c1cncc(Br)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.59
HCAR2 Q8TDS4 1/20 0.59
HTT P42858 4/20 0.51
ALOX15 P16050 2/20 0.51
CASP3 P42574 2/20 0.49
RAB9A P51151 1/20 0.49
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 3/20 0.47
MAPK1 P28482 2/20 0.47
USP2 O75604 1/20 0.47
TP53 P04637 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
GAA P10253 2/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
PKM P14618 1/20 0.43
ROCK2 O75116 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27747159 0.87 POLB (0.56) POLBHCAR2HTTALOX15CASP3
SCHEMBL10136683 0.84 POLB (0.60) POLBHCAR2HTTALOX15CASP3
SCHEMBL6133363 0.83 POLB (0.56) POLBHCAR2HTTALOX15CASP3
SCHEMBL6133431 0.82 POLB (0.63) POLBHCAR2HTTALOX15CASP3
Ethane SCHEMBL28837432 0.76 HCAR2 (0.92) POLBHCAR2HTTALOX15RAB9A
SCHEMBL5159945 0.76 HCAR2 (0.52) POLBHCAR2KDM4EALDH1A1MEN1
SCHEMBL112388 0.75 HCAR2 (1.00) POLBHCAR2HTTALOX15RAB9A
SCHEMBL29603529 0.75 HCAR2 (1.00) POLBHCAR2HTTALOX15RAB9A
SCHEMBL28567525 0.74 CHRNA1 (0.55) HTTCASP3RAB9AALDH1A1TP53
Cadaverine Tartrate SCHEMBL27897221 0.74 HTT (0.67) POLBHCAR2HTTALOX15CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013033901-A1 HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2013-03-14 WO disclosed
WO-2013034047-A1 HETEROCYCLIC-SUBSTITUED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2013-03-14 WO disclosed