⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30321851 | 0.85 | BRD4 (0.46) | — | |
| SCHEMBL22590576 | 0.85 | BRD4 (0.46) | — | |
| SCHEMBL14772646 | 0.85 | BRD4 (0.46) | — | |
| SCHEMBL14764796 | 0.83 | — | — | |
| SCHEMBL14764735 | 0.80 | BRD4 (0.40) | — | |
| SCHEMBL31507049 | 0.80 | DRD2 (0.61) | — | |
| SCHEMBL1043853 | 0.80 | DRD2 (0.61) | — | |
| SCHEMBL23030385 | 0.78 | XIAP (0.39) | — | |
| SCHEMBL18388426 | 0.78 | DRD2 (0.62) | — | |
| SCHEMBL14764690 | 0.77 | CA12 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130904-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2026-05-14 | — | — | US | disclosed |
| US-20230099694-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-03-30 | — | — | US | disclosed |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-02-25 | — | — | US | disclosed |
| US-20210052575-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-02-25 | — | — | US | disclosed |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-02-27 | — | — | US | disclosed |
| US-20200061056-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-02-27 | — | — | US | disclosed |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
| US-20180318294-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-11-08 | — | — | US | disclosed |
| US-20180092907-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-05 | — | — | US | disclosed |
| EP-2753617-B1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMA CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| US-9260420-B2 | Piperazine-substituted benzothiophene derivatives as antipsychotic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-9260420-B2 | Piperazine-substituted benzothiophene derivatives as antipsychotic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-9260420-B2 | Piperazine-substituted benzothiophene derivatives as antipsychotic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-20150045356-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-02-12 | — | — | US | disclosed |
| US-20150045356-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-02-12 | — | — | US | disclosed |
| US-20150045356-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-02-12 | — | — | US | disclosed |
| CN-103781783-A | Piperazine-substituted benzothiophene derivatives as antipsychotic agents | OTSUKA PHARMA CO LTD | 2014-05-07 | — | — | CN | disclosed |
| WO-2013035892-A1 | PIPERAZINE- SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013035892-A1 | PIPERAZINE- SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-14 | — | — | WO | disclosed |