Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 9/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR5A | P47898 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765075 | 0.87 | CREBBP (0.54) | CREBBPBRPF1BRD4GSK3BCHEK1 | |
| SCHEMBL19657751 | 0.78 | CREBBP (0.59) | CREBBPBRPF1BRD4GSK3BKMT2A | |
| SCHEMBL30858659 | 0.78 | CREBBP (0.59) | CREBBPBRPF1BRD4GSK3BKMT2A | |
| SCHEMBL19657315 | 0.77 | CREBBP (0.58) | CREBBPBRPF1BRD4GSK3BTSHR | |
| SCHEMBL31606394 | 0.77 | CREBBP (0.58) | CREBBPBRPF1BRD4GSK3BTSHR | |
| SCHEMBL5732983 | 0.75 | CREBBP (0.46) | CREBBPBRPF1BRD4CHEK1KMT2A | |
| SCHEMBL21024074 | 0.74 | CREBBP (0.54) | CREBBPBRPF1BRD4GSK3BALDH1A1 | |
| SCHEMBL22822416 | 0.74 | CREBBP (0.54) | CREBBPBRPF1BRD4GSK3BALDH1A1 | |
| SCHEMBL7174583 | 0.73 | BRPF1 (0.52) | CREBBPBRPF1BRD4GSK3BKMT2A | |
| SCHEMBL1101924 | 0.71 | CREBBP (1.00) | CREBBPBRPF1BRD4GSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |