Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 7/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764815 | 0.81 | MAP2K4 (0.51) | ELANEIDO1 | |
| SCHEMBL4782417 | 0.72 | ATM (0.46) | ATMLMNAELANEALDH1A1ASAH1 | |
| SCHEMBL2304878 | 0.70 | ELANE (0.55) | ATMLMNAELANEALDH1A1MAPT | |
| SCHEMBL30910158 | 0.69 | ALDH1A1 (0.40) | ELANEEGFRALDH1A1KDM4EKMT2A | |
| SCHEMBL30204980 | 0.69 | MAPT (0.42) | ATMLMNAKMT2ACNR1MAPT | |
| SCHEMBL3635142 | 0.69 | MAP2K4 (0.55) | ELANEKDM4EKMT2AMAPT | |
| SCHEMBL2731864 | 0.68 | MAP2K4 (0.49) | ELANEKMT2A | |
| SCHEMBL2300687 | 0.68 | ELANE (0.53) | ATMLMNAELANEALDH1A1MAPT | |
| SCHEMBL27788236 | 0.67 | ELANE (0.48) | ATMELANEKDM4EKMT2AMAPT | |
| SCHEMBL30910159 | 0.67 | HRH2 (0.38) | ALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033899-A1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-14 | — | — | WO | disclosed |