Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.67 |
| ▸ | PDE6D | O43924 | 4/20 | 0.47 |
| ▸ | PDE6A | P16499 | 4/20 | 0.47 |
| ▸ | PDE6G | P18545 | 4/20 | 0.47 |
| ▸ | PDE6B | P35913 | 4/20 | 0.47 |
| ▸ | PDE6C | P51160 | 4/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765106 | 0.92 | PDE2A (0.73) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14764861 | 0.87 | PDE2A (0.78) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL16081702 | 0.82 | PDE2A (0.60) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765020 | 0.81 | PDE2A (0.65) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765096 | 0.80 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765076 | 0.78 | PDE2A (0.72) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL16052929 | 0.77 | PDE2A (0.67) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765055 | 0.77 | PDE2A (0.71) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14764851 | 0.77 | PDE2A (0.71) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14764825 | 0.77 | PDE10A (0.58) | PDE2APDE10APDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2014139983-A1 | [1,2,4]TRIAZOLO[4,3-A]QUINOXALINES AS DUAL PDE2/PDE10 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014139983-A1 | [1,2,4]TRIAZOLO[4,3-A]QUINOXALINES AS DUAL PDE2/PDE10 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |