Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.58 |
| ▸ | PDE2A | O00408 | 6/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765187 | 0.77 | PDE2A (0.67) | PDE10APDE2APDE4DPDE4A | |
| SCHEMBL14765127 | 0.76 | PDE2A (0.53) | PDE10APDE2A | |
| SCHEMBL14764861 | 0.75 | PDE2A (0.78) | PDE10APDE2APDE4DPDE5APDE4A | |
| SCHEMBL14764575 | 0.73 | PDE10A (0.56) | PDE10APDE2APDE4DPDE4A | |
| SCHEMBL14765096 | 0.73 | PDE2A (1.00) | PDE10APDE2APDE4DPDE3APDE4A | |
| SCHEMBL14764851 | 0.73 | PDE2A (0.71) | PDE10APDE2APDE4DPDE4A | |
| SCHEMBL14765106 | 0.72 | PDE2A (0.73) | PDE10APDE2APDE4DPDE4A | |
| SCHEMBL16081702 | 0.72 | PDE2A (0.60) | PDE10APDE2APDE4DPDE4AGAA | |
| SCHEMBL14765020 | 0.71 | PDE2A (0.65) | PDE10APDE2APDE4DPDE4APDE11A | |
| SCHEMBL14765076 | 0.71 | PDE2A (0.72) | PDE10APDE2APDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |