Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 5/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771892 | 0.88 | USP30 (0.48) | AAK1USP30GPR119TBK1 | |
| SCHEMBL18339778 | 0.84 | USP30 (0.51) | AAK1USP30GPR119TBK1PDE4B | |
| SCHEMBL14771879 | 0.83 | XDH (0.40) | USP30XDHIKBKETBK1 | |
| SCHEMBL18340579 | 0.82 | USP30 (0.45) | AAK1USP30PRMT5WDR77GPR119 | |
| SCHEMBL14764910 | 0.82 | AAK1 (0.48) | AAK1XDHGPR119PDE4APDE4B | |
| SCHEMBL17323930 | 0.81 | USP30 (0.47) | AAK1USP30GPR119TBK1PDE4B | |
| SCHEMBL14764058 | 0.81 | XDH (0.41) | XDHIKBKETBK1 | |
| SCHEMBL16491266 | 0.79 | USP30 (0.41) | AAK1USP30PRMT5WDR77GPR119 | |
| SCHEMBL14764331 | 0.79 | XDH (0.43) | XDHIKBKETBK1 | |
| SCHEMBL23810495 | 0.77 | AAK1 (0.46) | AAK1PRMT5WDR77DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034238-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-03-14 | — | — | WO | disclosed |