Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756085 | 0.81 | KDR (0.34) | JAK2NR1D1KDR | |
| SCHEMBL530189 | 0.81 | CDK2 (0.40) | KDRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL23992867 | 0.75 | HTR2C (0.35) | JAK2NR1D1DYRK1ADYRK2KCNQ3 | |
| SCHEMBL23995238 | 0.75 | HTR2C (0.35) | JAK2NR1D1DYRK1ADYRK2KCNQ3 | |
| SCHEMBL2588629 | 0.73 | DYRK3 (0.45) | DYRK1ADYRK2KDRCYP19A1CYP11B1 | |
| SCHEMBL1346284 | 0.73 | JAK2 (0.40) | JAK2DYRK1AKCNQ3KCNQ2KIF11 | |
| SCHEMBL29892546 | 0.72 | JAK2 (0.39) | JAK2DYRK1AKCNQ3KCNQ2KIF11 | |
| SCHEMBL30224440 | 0.71 | ERN1 (0.40) | JAK2 | |
| SCHEMBL23993369 | 0.70 | RAF1 (0.35) | NR1D1BRAFKDR | |
| SCHEMBL23993376 | 0.70 | RAF1 (0.35) | NR1D1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034048-A1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-14 | — | — | WO | disclosed |