Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588629 | 0.85 | DYRK3 (0.45) | CDK2CCNA2KDM4EALDH1A1KDR | |
| SCHEMBL10756085 | 0.84 | KDR (0.34) | HPGDADORA2AAKT1AKT2KDR | |
| SCHEMBL14765267 | 0.81 | JAK2 (0.45) | KDRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL17303162 | 0.77 | APOBEC3A (0.48) | CDK2CCNE1SYKKDM4EALDH1A1 | |
| SCHEMBL2594102 | 0.75 | CYP11B2 (0.52) | — | |
| SCHEMBL1202802 | 0.74 | CDK2 (0.45) | CDK2CCNE1CCNA2KDRIRAK4 | |
| SCHEMBL23994765 | 0.74 | ADCY10 (0.38) | SYKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1826192 | 0.73 | GRIN2D (0.33) | ALDH1A1 | |
| SCHEMBL3700079 | 0.72 | AKT1 (0.42) | AKT1AKT2 | |
| SCHEMBL2591526 | 0.72 | CYP17A1 (0.43) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987273-B2 | Substituted imidazo[1,2-B]pyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2598505-B1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES | BAYER IP GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |
| US-20130210825-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| EP-2598505-A2 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013713-A2 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210825-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES | NRAS, IDH2, NDUFB1 | CDK2 158/4885CCNE1 457/4885SYK 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.