Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15080735 | 0.93 | ABCB1 (0.30) | ABCB1 | |
| SCHEMBL13618634 | 0.91 | ABCB1 (0.32) | ABCB1 | |
| SCHEMBL15080494 | 0.91 | ABCB1 (0.32) | ABCB1 | |
| SCHEMBL18481586 | 0.87 | ABCB1 (0.31) | ABCB1 | |
| SCHEMBL18542716 | 0.86 | — | — | |
| SCHEMBL20094859 | 0.86 | — | — | |
| SCHEMBL18542717 | 0.86 | — | — | |
| SCHEMBL17813072 | 0.86 | — | — | |
| SCHEMBL19844434 | 0.86 | ABCB1 (0.31) | ABCB1 | |
| SCHEMBL14986302 | 0.86 | ABCB1 (0.31) | ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580467-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | E. R. SQUIBB & SONS, L.L.C. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160060294-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2016-03-03 | — | — | US | disclosed |
| US-9226974-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | E. R. SQUIBB & SONS, L.L.C. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20140323690-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2014-10-30 | — | — | US | disclosed |
| EP-2461830-B1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8802632-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8772542-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772543-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130204033-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130197259-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130189256-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8476451-B2 | Tubulysin D analogues | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-8394922-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20110263650-A1 | Tubulysin D Analogues | HELMHOLTZ-ZENTRUM FÜR INFEKTIONS-FORSCHUNG GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110027274-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110021568-A1 | TUBULYSIN D ANALOGUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060294-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20110027274-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20130189256-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20140323690-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20130197259-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20110263650-A1 | Tubulysin D Analogues | NGLY1, TEKT1, TEK | ABCB1 2787/4885 |
| US-20130204033-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885 |
| US-20110021568-A1 | TUBULYSIN D ANALOGUES | TEK, NGLY1, TEKT1 | ABCB1 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.