Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR2 | Q13873 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 7/20 | 0.35 |
| ▸ | HTR1D | P28221 | 6/20 | 0.35 |
| ▸ | HTR1B | P28222 | 6/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 11/20 | 0.34 |
| ▸ | FLT3 | P36888 | 11/20 | 0.34 |
| ▸ | JAK2 | O60674 | 10/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL463821 | 0.92 | BMPR2 (0.38) | BMPR2HTR1AHTR1DHTR1BPLK4 | |
| SCHEMBL415037 | 0.92 | BMPR2 (0.38) | BMPR2PLK4CDK2FLT3JAK2 | |
| SCHEMBL414518 | 0.82 | BMPR2 (0.39) | BMPR2CDK2FLT3JAK2CCNA2 | |
| SCHEMBL14765621 | 0.81 | CHEK1 (0.41) | JAK2JAK1TYK2MAP4K3JAK3 | |
| SCHEMBL416119 | 0.80 | ALK (0.40) | FLT3JAK2JAK1TYK2JAK3 | |
| SCHEMBL10291311 | 0.78 | BMPR2 (0.39) | BMPR2CDK2FLT3JAK2CCNA2 | |
| SCHEMBL415035 | 0.78 | BMPR2 (0.39) | BMPR2CDK2FLT3JAK2CCNA2 | |
| SCHEMBL10290794 | 0.78 | CHEK1 (0.37) | FLT3JAK2JAK1TYK2MAP4K3 | |
| SCHEMBL14765637 | 0.78 | MAP4K1 (0.37) | CDK2FLT3JAK2CCNA2CCNA1 | |
| SCHEMBL14765623 | 0.78 | CHEK1 (0.35) | FLT3JAK2JAK1TYK2MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |