Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765637 | 0.93 | MAP4K1 (0.37) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL14765621 | 0.92 | CHEK1 (0.41) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL463855 | 0.92 | JAK2 (0.35) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL414486 | 0.92 | CHEK1 (0.39) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL14765618 | 0.89 | JAK2 (0.36) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL10280140 | 0.88 | JAK2 (0.37) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL415980 | 0.87 | JAK2 (0.41) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL14765620 | 0.86 | MAP4K1 (0.34) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL14765638 | 0.85 | CHEK1 (0.41) | CHEK1MAP4K1MAP4K3AXLFLT3 | |
| SCHEMBL10290549 | 0.85 | CHEK1 (0.40) | CHEK1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |