Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK3 | Q13188 | 10/20 | 0.68 |
| ▸ | STK4 | Q13043 | 10/20 | 0.67 |
| ▸ | EGFR | P00533 | 7/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.67 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | STK25 | O00506 | 1/20 | 0.65 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.65 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.65 |
| ▸ | STK17B | O94768 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10054547 | 0.91 | STK4 (0.78) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL14765634 | 0.91 | STK3 (0.82) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL2388105 | 0.91 | STK3 (0.83) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL33529039 | 0.91 | STK3 (0.83) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL10054548 | 0.84 | STK4 (0.76) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL14765643 | 0.84 | STK4 (0.66) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL2384343 | 0.84 | STK3 (0.85) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL33531997 | 0.84 | STK3 (0.85) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL12309393 | 0.83 | STK4 (0.77) | STK3STK4EGFRERBB2SRC | |
| SCHEMBL2387968 | 0.83 | STK3 (0.86) | STK3STK4EGFRERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394959-B2 | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-buteramide and crystalline forms thereof | WYETH LLC (US) | 2013-03-12 | — | — | US | disclosed |