Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR2 | Q13873 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280013 | 0.90 | BMPR2 (0.37) | BMPR2GSK3AGSK3B | |
| SCHEMBL415046 | 0.88 | BMPR2 (0.37) | BMPR2GSK3AGSK3B | |
| SCHEMBL14765622 | 0.84 | MAP4K1 (0.35) | — | |
| SCHEMBL13301723 | 0.83 | BMPR2 (0.40) | BMPR2GSK3AGSK3B | |
| SCHEMBL415990 | 0.82 | BMPR2 (0.40) | BMPR2GSK3AGSK3B | |
| SCHEMBL416074 | 0.82 | BMPR2 (0.40) | BMPR2GSK3AGSK3B | |
| SCHEMBL14765639 | 0.79 | MAP4K1 (0.34) | — | |
| SCHEMBL415056 | 0.78 | BMPR2 (0.36) | BMPR2GSK3AGSK3B | |
| SCHEMBL414534 | 0.75 | GSK3A (0.37) | BMPR2GSK3AGSK3B | |
| SCHEMBL416082 | 0.74 | CHEK1 (0.41) | BMPR2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |