Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 6/20 | 0.33 |
| ▸ | MERTK | Q12866 | 6/20 | 0.33 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765622 | 0.96 | MAP4K1 (0.35) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL463857 | 0.90 | MERTK (0.34) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL415982 | 0.89 | JAK2 (0.34) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL414498 | 0.84 | JAK2 (0.36) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL463809 | 0.84 | MAP4K1 (0.35) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL14765620 | 0.83 | MAP4K1 (0.34) | MAP4K1MAP4K3TYRO3MERTKAXL | |
| SCHEMBL14765618 | 0.80 | JAK2 (0.36) | MAP4K1MAP4K3TYRO3MERTKNTRK1 | |
| SCHEMBL414475 | 0.80 | JAK2 (0.38) | — | |
| SCHEMBL413912 | 0.80 | JAK2 (0.39) | — | |
| SCHEMBL463865 | 0.80 | JAK2 (0.34) | MAP4K1MAP4K3TYRO3MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |