Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.36 |
| ▸ | JAK1 | P23458 | 9/20 | 0.36 |
| ▸ | TYK2 | P29597 | 9/20 | 0.36 |
| ▸ | JAK3 | P52333 | 9/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 5/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280140 | 0.92 | JAK2 (0.37) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL415980 | 0.91 | JAK2 (0.41) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL14765623 | 0.89 | CHEK1 (0.35) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL414486 | 0.88 | CHEK1 (0.39) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL463855 | 0.88 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL14765622 | 0.85 | MAP4K1 (0.35) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL14765637 | 0.82 | MAP4K1 (0.37) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL14765621 | 0.82 | CHEK1 (0.41) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL10290549 | 0.81 | CHEK1 (0.40) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL14765639 | 0.80 | MAP4K1 (0.34) | MAP4K1MAP4K3NTRK1CYP3A4CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |