Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152910 | 0.83 | MRGPRX4 (0.53) | ALDH1A1KDM4EMRGPRX4MAPTKMT2A | |
| SCHEMBL3154937 | 0.80 | MRGPRX4 (0.57) | NPC1ALDH1A1MRGPRX4POLBRAB9A | |
| SCHEMBL11310133 | 0.79 | MEN1 (0.55) | NPC1ALDH1A1KDM4EMAPK1POLB | |
| SCHEMBL14765644 | 0.78 | NPC1 (0.50) | NPC1ALDH1A1KDM4EMRGPRX4RAB9A | |
| SCHEMBL3148906 | 0.77 | MRGPRX4 (0.53) | NPC1ALDH1A1KDM4EMRGPRX4POLB | |
| SCHEMBL1121567 | 0.76 | NPC1 (0.59) | NPC1ALDH1A1KDM4EMAPK1RAB9A | |
| SCHEMBL3156034 | 0.74 | MAPT (0.47) | NPC1ALDH1A1KDM4EMAPK1MRGPRX4 | |
| SCHEMBL3143386 | 0.73 | MRGPRX4 (0.57) | NPC1ALDH1A1MRGPRX4POLBRAB9A | |
| SCHEMBL13356594 | 0.72 | NPC1 (0.60) | NPC1ALDH1A1KDM4EMAPK1POLB | |
| SCHEMBL4297004 | 0.72 | POLB (0.59) | NPC1ALDH1A1KDM4EMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394799-B2 | Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2013-03-12 | — | — | US | disclosed |