Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | RHEB | Q15382 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148681 | 0.83 | MRGPRX4 (0.52) | NPC1RAB9ARHEBCYP1A2CYP3A4 | |
| SCHEMBL3152589 | 0.80 | RAB9A (0.57) | NPC1RAB9ARHEBMAPTHSD17B10 | |
| SCHEMBL23709934 | 0.79 | RHEB (0.63) | RHEBMAPTHSD17B10MRGPRX4KDM4E | |
| SCHEMBL3143457 | 0.79 | ALDH1A1 (0.53) | NPC1RAB9ARHEBCYP1A2CYP3A4 | |
| SCHEMBL14765645 | 0.78 | NPC1 (0.47) | NPC1RAB9ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7689491 | 0.76 | RAB9A (0.60) | NPC1RAB9ARHEBMAPTHSD17B10 | |
| SCHEMBL20424542 | 0.76 | SMN1; SMN2 (0.47) | NPC1RAB9AMAPTHSD17B10MEN1 | |
| SCHEMBL2242937 | 0.75 | RAB9A (0.70) | NPC1RAB9AMAPTHSD17B10MEN1 | |
| SCHEMBL3153713 | 0.73 | RAB9A (0.57) | NPC1RAB9ARHEBMAPTHSD17B10 | |
| SCHEMBL23589337 | 0.72 | SMN1; SMN2 (0.45) | NPC1RAB9AMAPTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394799-B2 | Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2013-03-12 | — | — | US | disclosed |