Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000118 | 0.88 | ALDH1A1 (0.39) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL20575884 | 0.85 | MAPT (0.35) | CA1CA2TDP1KMT2APOLB | |
| SCHEMBL1461811 | 0.83 | CA1 (0.37) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL912809 | 0.82 | CA1 (0.34) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL9964313 | 0.77 | TYMP (0.30) | — | |
| SCHEMBL20725671 | 0.75 | ALDH1A1 (0.35) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL1490930 | 0.74 | ALDH1A1 (0.39) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL14574716 | 0.73 | CA1 (0.32) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL29562425 | 0.72 | KMT2A (0.47) | CA1CA2TDP1KMT2ASLC6A2 | |
| SCHEMBL913073 | 0.72 | KMT2A (0.47) | CA1CA2TDP1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394795-B2 | Pyrazole [3, 4-B] pyridine Raf inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-03-12 | — | — | US | disclosed |