Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15605543 | 1.00 | HTR1A (0.41) | HTR1ASLC6A2CHRNB2CHRNA4MKNK1 | |
| SCHEMBL10257945 | 1.00 | HTR1A (0.41) | HTR1ASLC6A2CHRNB2CHRNA4MKNK1 | |
| SCHEMBL6015953 | 0.93 | HTR1A (0.41) | HTR1ASLC6A2CHRNB2CHRNA4 | |
| SCHEMBL6015696 | 0.93 | HTR1A (0.41) | HTR1ASLC6A2CHRNB2CHRNA4 | |
| SCHEMBL6015807 | 0.93 | HRH1 (0.41) | HTR1ASLC6A2MKNK1MKNK2SLC6A4 | |
| SCHEMBL2421529 | 0.85 | MCHR1 (0.41) | MKNK1MKNK2 | |
| SCHEMBL12322176 | 0.85 | MCHR1 (0.39) | MKNK1MKNK2HTR2CHTR2B | |
| SCHEMBL2421021 | 0.84 | MCHR1 (0.43) | MKNK1MKNK2 | |
| SCHEMBL620797 | 0.82 | KAT2B (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL10257428 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013158928-A2 | CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES | ELCELYX THERAPEUTICS, INC. (US) | 2013-10-24 | — | — | WO | disclosed |
| EP-2573559-A1 | Modulation of chemosensory receptors and ligands associated | Senomyx, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2568287-A2 | Modulation of chemosensory receptors and ligands associated | Senomyx, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |