Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 8/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.35 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769545 | 0.86 | S1PR2 (0.34) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL16476635 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1HPGDNQO2SMN1; SMN2 | |
| SCHEMBL16387727 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2S1PR2MAPT | |
| SCHEMBL23970957 | 0.69 | TUBB4A (0.49) | KDM4EL3MBTL1ALDH1A1HPGDNQO2 | |
| SCHEMBL30411382 | 0.69 | TUBB4A (0.49) | KDM4EL3MBTL1ALDH1A1HPGDNQO2 | |
| SCHEMBL17137842 | 0.68 | TDP1 (0.64) | KDM4ETDP1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL30612180 | 0.67 | KDM4E (0.56) | KDM4EL3MBTL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL26106242 | 0.67 | KDM4E (0.56) | KDM4EL3MBTL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL14816670 | 0.67 | TDP1 (0.45) | KDM4ETDP1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL23142710 | 0.66 | NR4A2 (0.37) | ALDH1A1ADCY10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013037390-A1 | 6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2013-03-21 | — | — | WO | disclosed |
| EP-2567959-A1 | 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors | SANOFI (FR) | 2013-03-13 | — | — | EP | disclosed |