Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 11/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768347 | 0.85 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1882069 | 0.81 | PIK3CD (0.39) | PFKFB3PIK3CDPIK3R2PIK3CAPIK3CG | |
| SCHEMBL1882072 | 0.81 | PIK3CD (0.39) | PFKFB3PIK3CDPIK3R2PIK3CAPIK3CG | |
| SCHEMBL14768337 | 0.81 | GAA (0.38) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL1890692 | 0.80 | FGFR1 (0.35) | PFKFB3PIK3CDPIK3R2PIK3CAPIK3CG | |
| SCHEMBL716189 | 0.77 | TSHR (0.47) | PIK3CD | |
| SCHEMBL14768191 | 0.76 | IDH1 (0.35) | PFKFB3PIK3CDIDH1 | |
| SCHEMBL1883829 | 0.76 | IDH1 (0.35) | PFKFB3PIK3CDIDH1 | |
| SCHEMBL715520 | 0.75 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL15875803 | 0.75 | TSHR (0.38) | PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399483-B2 | Quinoxaline and quinoline derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2013-03-19 | — | — | US | disclosed |