Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768347 | 0.87 | PIK3CD (0.39) | PIK3CDPIK3CGATM | |
| SCHEMBL14768204 | 0.81 | PFKFB3 (0.39) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL1881740 | 0.79 | ADORA2A (0.36) | GAAMAPTTP53SMN1; SMN2PIK3CD | |
| SCHEMBL14768191 | 0.78 | IDH1 (0.35) | SMN1; SMN2PIK3CDATM | |
| SCHEMBL1883829 | 0.78 | IDH1 (0.35) | SMN1; SMN2PIK3CDATM | |
| SCHEMBL716189 | 0.75 | TSHR (0.47) | GAAMAPTSMN1; SMN2PIK3CD | |
| SCHEMBL15875803 | 0.74 | TSHR (0.38) | GAAMAPTTP53SMN1; SMN2PIK3CD | |
| SCHEMBL715604 | 0.72 | PIK3CD (0.47) | SMN1; SMN2PIK3CD | |
| SCHEMBL715520 | 0.72 | PIK3CD (0.46) | GAAMAPTTP53SMN1; SMN2PIK3CD | |
| SCHEMBL1884628 | 0.72 | PIK3CD (0.40) | GAAMAPTTP53PIK3CDADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399483-B2 | Quinoxaline and quinoline derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2013-03-19 | — | — | US | disclosed |