Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.73 |
| ▸ | FLT4 | P35916 | 3/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | STK3 | Q13188 | 1/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.60 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768403 | 0.85 | CHEK1 (0.88) | CHEK1 | |
| SCHEMBL2595463 | 0.84 | CHEK1 (1.00) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| Hydrochloric Acid SCHEMBL2595386 | 0.84 | CHEK1 (0.98) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL14965385 | 0.82 | CHEK1 (0.74) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| Hydrochloric Acid SCHEMBL16195313 | 0.81 | CHEK1 (0.73) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL2593325 | 0.81 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL2595563 | 0.80 | CHEK1 (0.69) | CHEK1 | |
| SCHEMBL14761985 | 0.80 | CHEK1 (0.70) | CHEK1FLT4RPS6KA3RPS6KB1FLT3 | |
| SCHEMBL2593416 | 0.80 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL2593302 | 0.79 | CHEK1 (1.00) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716287-B2 | Pharmaceutical compounds | SENTINEL ONCOLOGY LIMITED (GB) | 2014-05-06 | — | — | US | disclosed |
| US-20130065900-A1 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065900-A1 | PHARMACEUTICAL COMPOUNDS | CSNK1A1, FRK, CSNK1E | CHEK1 105/4885FLT4 610/4885RPS6KA3 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.