Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.74 |
| ▸ | FLT4 | P35916 | 4/20 | 0.72 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.72 |
| ▸ | AURKA | O14965 | 3/20 | 0.72 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | CDK2 | P24941 | 2/20 | 0.72 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.72 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.72 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.72 |
| ▸ | RET | P07949 | 1/20 | 0.72 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.72 |
| ▸ | CLK2 | P49760 | 1/20 | 0.72 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.72 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.72 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.72 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.72 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16195313 | 0.99 | CHEK1 (0.73) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| Hydrochloric Acid SCHEMBL17684914 | 0.89 | CHEK1 (0.69) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL14965380 | 0.89 | CHEK1 (0.74) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| Hydrochloric Acid SCHEMBL16195311 | 0.88 | CHEK1 (0.73) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL18780355 | 0.86 | CHEK1 (0.76) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL21067794 | 0.86 | CHEK1 (1.00) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL14762224 | 0.84 | CHEK1 (0.71) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL18780403 | 0.84 | CHEK1 (0.76) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL18780302 | 0.84 | CHEK1 (0.76) | CHEK1FLT4RPS6KA3AURKAGSK3B | |
| SCHEMBL14768403 | 0.83 | CHEK1 (0.88) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780331-A1 | PHARMACEUTICALLY ACTIVE PYRAZINE DERIVATIVES | Sentinel Oncology Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072502-A1 | PHARMACEUTICALLY ACTIVE PYRAZINE DERIVATIVES | SENTINEL ONCOLOGY LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |