Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | CCR1 | P32246 | 4/20 | 0.54 |
| ▸ | CCR8 | P51685 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | CCR5 | P51681 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25184887 | 0.81 | LMNA (0.48) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL29953507 | 0.81 | LMNA (0.48) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL4539236 | 0.80 | LMNA (0.52) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL4700675 | 0.80 | LMNA (0.52) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL10087924 | 0.80 | LMNA (0.53) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL21657686 | 0.77 | LMNA (0.48) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL8404537 | 0.76 | LMNA (0.68) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL11379744 | 0.76 | LMNA (0.61) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL30492643 | 0.76 | LMNA (0.61) | LMNAKDM4EMAPTCCR1CCR8 | |
| SCHEMBL20897727 | 0.75 | PDE10A (0.61) | LMNAKDM4EMAPTCCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112204-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| WO-2013036548-A2 | ZIRCONIUM CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS | DOW CORNING CORPORATION (US) | 2013-03-14 | — | — | WO | disclosed |