Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.61 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589768 | 0.92 | HRH3 (0.66) | HRH3EGLN1ESR2LIPE | |
| SCHEMBL6137 | 0.92 | HRH3 (0.66) | HRH3EGLN1ESR2LIPE | |
| SCHEMBL10308 | 0.92 | HRH3 (0.66) | HRH3EGLN1ESR2LIPE | |
| SCHEMBL12185502 | 0.87 | HRH3 (0.73) | HRH3EGLN1ESR2KCNH2 | |
| SCHEMBL14760991 | 0.87 | HRH3 (0.73) | HRH3EGLN1ESR2KCNH2 | |
| SCHEMBL14769119 | 0.82 | HRH3 (0.56) | HRH3EGLN1LIPE | |
| SCHEMBL12303 | 0.82 | HRH3 (0.62) | HRH3EGLN1LIPE | |
| SCHEMBL9671 | 0.81 | HRH3 (0.60) | HRH3EGLN1ESR2 | |
| SCHEMBL1589959 | 0.80 | HRH3 (0.60) | HRH3EGLN1ESR2LIPE | |
| SCHEMBL10149 | 0.80 | HRH3 (0.60) | HRH3EGLN1ESR2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9453023-B2 | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof | SANOFI (FR) | 2016-09-27 | — | — | US | disclosed |
| US-20140275005-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-09-18 | — | — | US | disclosed |
| US-8735385-B2 | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| US-20130065877-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065877-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | PRLHR, TACR1, TACR2 | HRH3 14/4885EGLN1 1662/4885ESR2 832/4885 |
| US-20140275005-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | PRLHR, TACR1, TACR2 | HRH3 14/4885EGLN1 1662/4885ESR2 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.