Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148209 | 0.98 | KDM4E (0.44) | KDM4ECYP2C19CYP2D6KMT2APOLB | |
| Benzene SCHEMBL1818234 | 0.97 | KDM4E (0.43) | KDM4ECYP2C19CYP2D6KMT2APOLB | |
| Hydrochloric Acid SCHEMBL151393 | 0.97 | KDM4E (0.46) | KDM4ECYP2C19CYP2D6KMT2ANPC1 | |
| SCHEMBL1654139 | 0.97 | KDM4E (0.43) | KDM4ECYP2C19CYP2D6KMT2APOLB | |
| Acetic Acid SCHEMBL148715 | 0.94 | KDM4E (0.41) | KDM4ECYP2C19CYP2D6TSHRGAA | |
| Sulfuric Acid SCHEMBL147958 | 0.90 | KDM4E (0.38) | KDM4ECYP2C19CYP2D6ACHEPKM | |
| Sulfuric Acid SCHEMBL147959 | 0.90 | KDM4E (0.38) | KDM4ECYP2C19CYP2D6ACHETDP1 | |
| SCHEMBL148488 | 0.86 | KDM4E (0.36) | KDM4ECYP2C19CYP2D6KMT2APOLB | |
| SCHEMBL141770 | 0.83 | C5AR1 (0.38) | KDM4ECYP2D6SMN1; SMN2TSHRCYP3A4 | |
| Water SCHEMBL4556414 | 0.81 | KDM4E (0.41) | KDM4ECYP2C19CYP2D6KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315576-B1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO KGAA (DE) | 2013-12-25 | — | — | EP | claimed |
| US-8273332-B2 | Hair care product containing acetylpyridinium salts | HENKEL AG & CO. KGAA (DE) | 2012-09-25 | — | — | US | claimed |
| US-8246938-B2 | Hair care agent containing acetylpyridinium salts | HENKEL AG & CO. KGAA (DE) | 2012-08-21 | — | — | US | claimed |
| US-20120121528-A1 | Hair Care Agent Containing Acetylpyridinium Salts | HENKEL AG & CO. KGAA (DE) | 2012-05-17 | — | — | US | claimed |
| US-20120058071-A1 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | GROSS WIBKE (DE) | 2012-03-08 | — | — | US | claimed |
| US-8021438-B2 | Cationic acylpyridinium derivatives for use as bleach activators | HENKEL AG & CO. KGAA (DE) | 2011-09-20 | — | — | US | claimed |
| WO-2011082848-A2 | ANTIBACTERIAL AND BLEACHING ORAL AND DENTAL HYGIENE AND CLEANING AGENT II | HENKEL AG & CO. KGAA (DE) | 2011-07-14 | — | — | WO | claimed |
| US-20110146006-A1 | CATIONIC ACYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2011-06-23 | — | — | US | claimed |
| EP-2315576-A1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | Henkel AG & Co. KGaA (DE) | 2011-05-04 | — | — | EP | claimed |
| WO-2010022996-A1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2010-03-04 | — | — | WO | claimed |
| EP-2263642-B1 | Colouring bleaches | HENKEL AG & CO KGAA (DE) | 2020-04-15 | — | — | EP | disclosed |
| EP-2440174-B1 | AFTERTREATMENT FOR COLOR FIXATION | HENKEL AG & CO KGAA (DE) | 2014-12-17 | — | — | EP | disclosed |
| EP-2315576-B1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO KGAA (DE) | 2013-12-25 | — | — | EP | disclosed |
| US-8349023-B2 | After treatment for color fixation | HENKEL AG & CO. KGAA (DE) | 2013-01-08 | — | — | US | disclosed |
| US-8277516-B2 | Lightening agent having cationic acylpyridinium derivatives and certain ammonium compounds | HENKEL AG & CO. KGAA (DE) | 2012-10-02 | — | — | US | disclosed |
| WO-2010130513-A2 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | HENKEL AG & CO. KGAA (DE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010130526-A2 | HAIR CARE AGENT CONTAINING ACETYLPYRIDINIUM SALTS | HENKEL AG & CO. KGAA (DE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010054981-A2 | COMBINATION OF CATIONIC BLEACH ACTIVATORS AND DYES | HENKEL AG & CO. KGAA (DE) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010029006-A2 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2010-03-18 | — | — | WO | disclosed |
| WO-2010022996-A1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058071-A1 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | KAT7, EP300, CUTA | ACHE 739/4885KDM4E 2247/4885CYP2C19 2253/4885 |
| US-20120121528-A1 | Hair Care Agent Containing Acetylpyridinium Salts | KAT7, EP300, HDAC7 | ACHE 811/4885KDM4E 2816/4885CYP2C19 3241/4885 |
| US-20110146006-A1 | CATIONIC ACYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | KRT18, AADAC, KAT7 | ACHE 487/4885KDM4E 1245/4885CYP2C19 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.