Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769900 | 0.85 | PSMB5 (0.40) | PSMB5PSMB2 | |
| SCHEMBL14769882 | 0.81 | PSMB5 (0.37) | PSMB5PSMB2 | |
| SCHEMBL18268479 | 0.79 | PSMB5 (0.36) | PSMB5PSMB2 | |
| SCHEMBL12643196 | 0.78 | PSMB5 (0.39) | PSMB5PSMB2 | |
| SCHEMBL26733394 | 0.77 | PSMB5 (0.42) | PSMB5PSMB2 | |
| SCHEMBL12643203 | 0.76 | PSMB5 (0.38) | PSMB5PSMB2 | |
| SCHEMBL14769875 | 0.75 | PSMB5 (0.37) | PSMB5PSMB2 | |
| SCHEMBL13284881 | 0.75 | PSMB5 (0.52) | PSMB5PSMB2 | |
| SCHEMBL14769884 | 0.73 | PSMB5 (0.39) | PSMB5PSMB2 | |
| SCHEMBL12643205 | 0.72 | PSMB5 (0.38) | PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783572-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783572-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160347790-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-01 | — | — | US | disclosed |
| US-20160347790-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-01 | — | — | US | disclosed |
| US-9359309-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359309-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-06-07 | — | — | US | disclosed |
| US-20160108007-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-04-21 | — | — | US | disclosed |
| US-20160108007-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-04-21 | — | — | US | disclosed |
| US-9221772-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221772-B2 | Synthesis of syrbactin proteasome inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130065872-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-14 | — | — | US | disclosed |
| US-20130065872-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347790-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | PSMC4, PSMG3, PSMC5 | PSMB5 10/4885PSMB2 9/4885 |
| US-20130065872-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | PSMC4, PSMG3, PSMC5 | PSMB5 10/4885PSMB2 9/4885 |
| US-20160108007-A1 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS | PSMC4, PSMG3, PSMC5 | PSMB5 10/4885PSMB2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.