PSMG3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL30510662	0.76	1/20
SCHEMBL29454426	0.64	1/20
SCHEMBL8855414	0.61	1/20
SCHEMBL8855515	0.61	1/20
SCHEMBL8855442	0.60	1/20
Thielocin B3 (SCHEMBL29711143)	0.58	1/20
SCHEMBL29711773	0.54	1/20
SCHEMBL9043305	0.53	1/20
SCHEMBL9566948	0.52	1/20
SCHEMBL10474965	0.51	1/20
SCHEMBL8592611	0.51	1/20
SCHEMBL20313458	0.51	1/20
SCHEMBL8986770	0.51	1/20
SCHEMBL8591400	0.50	1/20
SCHEMBL8591659	0.50	1/20
SCHEMBL8591931	0.49	1/20
SCHEMBL8594227	0.49	1/20
SCHEMBL8595115	0.49	1/20
SCHEMBL8855399	0.49	1/20
SCHEMBL9057347	0.49	1/20

Clinical trials — most relevant to PSMG3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease	PHASE4	UNKNOWN
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Doxorubicin and Bortezomib in Treating Patients With Liver Cancer	PHASE2	COMPLETED
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
Colchicine for Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer	PHASE2	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas	PHASE1	COMPLETED
A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis	PHASE1	WITHDRAWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
GO-203-2C + Bortezomib For Relapsed Or Refractory MM	PHASE1	WITHDRAWN
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma	PHASE1	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment	nan	UNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese Adults	nan	NOT_YET_RECRUITING
Quantification of GADD34 Expression in RA	nan	COMPLETED
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)	nan	UNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Clinical and Biochemical Features for the Identification of Dominant Calpainopathies	nan	UNKNOWN
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PSMG3 binder may also engage these)

Protein	Name	Similarity
Q2NKS3	—	1.000	Q2NKS3 →
Q9CZH3	—	1.000	Q9CZH3 →
A7SP74	—	0.988	A7SP74 →
P0C7N9	—	0.986	P0C7N9 →
Q8N668	—	0.986	Q8N668 →
A5DNK9	—	0.985	A5DNK9 →
Q7YRD0	—	0.984	Q7YRD0 →
Q9STV0	—	0.984	Q9STV0 →
Q5JS54	—	0.984	Q5JS54 →
Q9P7J0	—	0.984	Q9P7J0 →
Q4D248	—	0.984	Q4D248 →
A8WN14	—	0.984	A8WN14 →
Q4DW94	—	0.984	Q4DW94 →
Q6CUA5	—	0.984	Q6CUA5 →
Q6VEU3	—	0.983	Q6VEU3 →
Q9NRX1	—	0.983	Q9NRX1 →
Q4V9P9	—	0.983	Q4V9P9 →
A6ZTA5	—	0.983	A6ZTA5 →
P38751	—	0.983	P38751 →
Q759J5	—	0.983	Q759J5 →
B3LSV9	—	0.982	B3LSV9 →
Q22006	—	0.982	Q22006 →
Q03460	—	0.982	Q03460 →
P25559	—	0.982	P25559 →
A4I4C5	—	0.982	A4I4C5 →
A8E7G4	—	0.982	A8E7G4 →
C5DLA7	—	0.982	C5DLA7 →
C7GRM1	—	0.982	C7GRM1 →
O14251	—	0.982	O14251 →
E9PVA8	—	0.982	E9PVA8 →