Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 9/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477998 | 0.84 | GRM5 (0.42) | GRM5FFAR1 | |
| SCHEMBL1476391 | 0.83 | GRM5 (0.50) | CHRNB2CHRNA4GRM5ALDH1A1FFAR1 | |
| SCHEMBL1477787 | 0.83 | CHRNB2 (0.45) | CHRNB2CHRNA4GRM5 | |
| SCHEMBL1477568 | 0.80 | CHRNB2 (0.40) | CHRNB2CHRNA4GRM5EGLN1ALDH1A1 | |
| SCHEMBL1477570 | 0.80 | CHRNB2 (0.40) | CHRNB2CHRNA4GRM5EGLN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1477673 | 0.78 | CHRNB2 (0.39) | CHRNB2CHRNA4GRM5EGLN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1477675 | 0.78 | CHRNB2 (0.39) | CHRNB2CHRNA4GRM5EGLN1ALDH1A1 | |
| SCHEMBL1814707 | 0.78 | PTGS1 (0.44) | GRM5ALDH1A1L3MBTL1FFAR1 | |
| SCHEMBL1477326 | 0.76 | CHRNB2 (0.40) | CHRNB2CHRNA4GRM5EGLN1EGLN3 | |
| SCHEMBL1477324 | 0.76 | CHRNB2 (0.40) | CHRNB2CHRNA4GRM5EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915424-B2 | Analgesics; anxiolytic agents | ELI LILLY AND COMPANY (US) | 2011-03-29 | — | — | US | disclosed |
| EP-1729771-B1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | disclosed |
| US-20080194647-A1 | Pyridyl Derivatives and Their Use as Mglu5 Antagonists | ELI LILLY AND COMPANY (US) | 2008-08-14 | — | — | US | disclosed |
| EP-1729771-A1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | Eli Lilly & Company (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094822-A1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194647-A1 | Pyridyl Derivatives and Their Use as Mglu5 Antagonists | HRH4, CNR2, CNR1 | CHRNB2 57/4885CHRNA4 6/4885GRM5 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.