Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.38 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.37 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14773110 | 0.86 | LCK (0.47) | GRM4EGFRERBB3LCKKDR | |
| SCHEMBL13857439 | 0.86 | GRM4 (0.42) | GRM4EGFRAURKAAURKBERBB3 | |
| SCHEMBL12262295 | 0.86 | MAP3K8 (0.49) | GRM4EGFRAURKAERBB3MAP3K8 | |
| SCHEMBL14773074 | 0.83 | LCLAT1 (0.42) | EGFRERBB3SGMS2PIP4K2APIP4K2B | |
| SCHEMBL14773113 | 0.83 | KMT2A (0.42) | EGFRERBB3POLBALDH1A1LMNA | |
| SCHEMBL14773096 | 0.81 | CCNT1 (0.42) | EGFRERBB3SGMS2PIP4K2APIP4K2B | |
| SCHEMBL14773100 | 0.79 | EGFR (0.47) | EGFRALDH1A1KDRLMNA | |
| SCHEMBL14773095 | 0.78 | BACE1 (0.42) | EGFRERBB3ERBB4JAK3KDR | |
| SCHEMBL14773072 | 0.77 | EGFR (0.63) | EGFRJAK3JAK1 | |
| SCHEMBL14773112 | 0.73 | MET (0.46) | EGFRERBB3ERBB4JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065892-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065892-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | GRM4 3866/4885EGFR 1981/4885AURKA 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.